Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis.

@article{Murthy2009ModulationOR,
  title={Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis.},
  author={S. Murthy and A. Adamcakova-Dodd and S. S. Perry and L. Tephly and R. M. Keller and N. Metwali and D. Meyerholz and Yongqiang Wang and M. Glogauer and P. Thorne and A. Carter},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={297 5},
  pages={
          L846-55
        }
}
The release of reactive oxygen species (ROS) and cytokines by alveolar macrophages has been demonstrated in asbestos-induced pulmonary fibrosis, but the mechanism linking alveolar macrophages to the pathogenesis is not known. The GTPase Rac1 is a second messenger that plays an important role in host defense. In this study, we demonstrate that Rac1 null mice are protected from asbestos-induced pulmonary fibrosis, as determined by histological and biochemical analysis. We hypothesized that Rac1… Expand
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