Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3.

@article{Du2013ModulationOR,
  title={Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3.},
  author={Te Du and Guoying Zhou and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 28},
  pages={E2621-8}
}
A key property of herpes simplex viruses (HSVs) is their ability to establish latent infection in sensory or autonomic ganglia and to reactivate on physical, hormonal, or emotional stress. In latently infected ganglia, HSV expresses a long noncoding RNA and a set of microRNAs, but viral proteins are not expressed. The mechanism by which latent HSV reactivates is unknown. A key question is, what is the mechanism of reactivation in the absence of tegument proteins that enable gene expression in… CONTINUE READING
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