Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males.

@article{Roset2001ModulationOR,
  title={Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males.},
  author={Pere Nolasc Roset and Mag{\'i} Farr{\'e} and Rafael de la Torre and M. Carmen Gonzalez Mas and Esther Menoyo and Caridad Mar{\'i}n Hern{\'a}ndez and Jordi Cam{\'i}},
  journal={Drug and alcohol dependence},
  year={2001},
  volume={64 3},
  pages={285-98}
}
Low, medium, and high doses of flunitrazepam were tested in three independent randomized, double-blind, balanced cross-over, placebo-controlled trials to study the influence of rate of onset of effects and dose administered on its acute effects. Three groups of 12 healthy male volunteers received six oral doses of placebo or flunitrazepam in slow and fast onset conditions as follows: six capsules of 0.16 mg (slow) and a single capsule of 0.8 mg (fast) in the low dose trial; six 0.25 mg (slow… CONTINUE READING

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