Modulation of rat platelet activation by vessel wall-derived prostaglandin and platelet-derived thromboxane: effects of dietary fish oil on thromboxane-prostaglandin balance.

Abstract

By dietary manipulation of rats with n-3 polyunsaturated fatty acids (PUFAs), platelets and endothelium-containing aortic tissue were obtained with decreased levels of arachidonate and increased levels of eicosapentaenoate and docosahexaenoate. These diet-induced changes were accompanied by a reduced formation of thromboxane A(2) (TXA(2)) and prostaglandin… (More)

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@article{Nieuwenhuys2001ModulationOR, title={Modulation of rat platelet activation by vessel wall-derived prostaglandin and platelet-derived thromboxane: effects of dietary fish oil on thromboxane-prostaglandin balance.}, author={C{\'e}cile M A Nieuwenhuys and Marion A. H. Feijge and R F Offermans and Arnold D. M. Kester and Gerard Hornstra and JWM. Heemskerk}, journal={Atherosclerosis}, year={2001}, volume={154 2}, pages={355-66} }