Modulation of rapid eye movement sleep in humans by drugs that modify monoaminergic and purinergic transmission.

@article{Nicholson1989ModulationOR,
  title={Modulation of rapid eye movement sleep in humans by drugs that modify monoaminergic and purinergic transmission.},
  author={Anthony N. Nicholson and Andrew J Belyavin and Peta A. Pascoe},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={1989},
  volume={2 2},
  pages={131-43}
}
Modulation of rapid eye movement (REM) sleep is a well-established effect of many centrally acting drugs. However, there is uncertainty concerning the nature of the changes and their significance, and it is in this context that we have analyzed the effects of several groups of drugs that alter monoaminergic or purinergic transmission on sleep in humans. The analysis shows that drugs that modulate noradrenergic and serotonergic transmission lead to marked suppression of REM sleep, irrespective… CONTINUE READING

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