Modulation of radiation response by histone deacetylase inhibition.

  title={Modulation of radiation response by histone deacetylase inhibition.},
  author={Prakash Chinnaiyan and Geetha Vallabhaneni and Eric A. Armstrong and S M Huang and Paul M. Harari},
  journal={International journal of radiation oncology, biology, physics},
  volume={62 1},
PURPOSE Histone deacetylase (HDAC) inhibitors, which modulate chromatin structure and gene expression, represent a class of anticancer agents that hold particular potential as radiation sensitizers. In this study, we examine the capacity of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) to modulate radiation response in human tumor cell lines and explore potential mechanisms underlying these interactions. METHODS AND MATERIALS Cell proliferation: Exponentially growing tumor cells… CONTINUE READING