Modulation of rabbit airway smooth muscle responsiveness by respiratory epithelium. Involvement of an inhibitory metabolite of arachidonic acid.

@article{Butler1987ModulationOR,
  title={Modulation of rabbit airway smooth muscle responsiveness by respiratory epithelium. Involvement of an inhibitory metabolite of arachidonic acid.},
  author={G. B. Butler and Kenneth B. Adler and John N. Evans and Douglas W. Morgan and John L Szarek},
  journal={The American review of respiratory disease},
  year={1987},
  volume={135 5},
  pages={1099-104}
}
The integrity of the respiratory epithelium may be important in development of bronchial hyperreactivity; however, the mechanisms involved remain unknown. This study was undertaken to determine if epithelium of rabbit intrapulmonary bronchi is capable of modulating the responsiveness of airway smooth muscle to a pharmacologic stimulus, and whether epithelial-derived prostaglandins play a role in this modulatory function. Mechanical removal of the epithelium from bronchial segments, or… CONTINUE READING