Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection.

@article{Nambiar2009ModulationOP,
  title={Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection.},
  author={Jonathan K Nambiar and Anthony A. Ryan and Carlyn U Kong and Warwick John Britton and James A Triccas},
  journal={European journal of immunology},
  year={2009},
  volume={40 1},
  pages={
          153-61
        }
}
The rational design of new vaccines engineered to target key components of the host immune response is crucial to aid control of important infectious diseases such as tuberculosis. In this report, we determined whether modifying the function of pulmonary APC could improve protection against infection with Mycobacterium tuberculosis. Targeted delivery to the lung of the cytokine GM-CSF, expressed by the Mycobacterium bovis BCG vaccine strain, increased pulmonary DC numbers and secretion of the… CONTINUE READING

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