Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures.

Abstract

Recent clinical observations have suggested that retinoids, which are in frequent use in dermatology, can affect the connective tissue metabolism in skin and other tissues. In this study, we examined the effects of several retinoids on the metabolism of collagen by human skin fibroblasts in culture. Incubation of cultured fibroblasts with all-trans-retinoic… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Oikarinen1985ModulationOP, title={Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures.}, author={Helj{\"a} Oikarinen and Aarne Oikarinen and Eng M Tan and R{\'e}my Abergel and Charles A Meeker and M. L. Chu and D. J. Prockop and J Uitto}, journal={The Journal of clinical investigation}, year={1985}, volume={75 5}, pages={1545-53} }