Modulation of presynaptic GABA(A) receptors by endogenous neurosteroids.

  title={Modulation of presynaptic GABA(A) receptors by endogenous neurosteroids.},
  author={B-G Kim and J Cho and I S Choi and M G Lee and I-S Jang},
  journal={British journal of pharmacology},
  volume={164 6},
BACKGROUND AND PURPOSE Although 3α-hydroxy, 5α-reduced pregnane steroids, such as allopregnanolone (AlloP) and tetrahydrodeoxycorticosterone, are endogenous positive modulators of postsynaptic GABA(A) receptors, the functional roles of endogenous neurosteroids in synaptic transmission are still largely unknown. EXPERIMENTAL APPROACH In this study, the effect of AlloP on spontaneous glutamate release was examined in mechanically isolated dentate gyrus hilar neurons by use of the conventional… CONTINUE READING
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