Modulation of polymyxin B effects on mammalian urinary bladder.

@article{Berg1998ModulationOP,
  title={Modulation of polymyxin B effects on mammalian urinary bladder.},
  author={Jamie R Berg and Christian M Spilker and Simon Andrew Lewis},
  journal={American journal of physiology. Renal physiology},
  year={1998},
  volume={275 2},
  pages={F204-F215}
}
This report demonstrates that Ca2+, Mg2+, and protons alter the ability of polymyxin B (PX, a cationic antibiotic used clinically as a bactericidal agent) to increase the apical membrane conductance of the rabbit urinary bladder. Using electrophysiological methods, we determine that these alterations occur by two mechanisms. First, they blocked the PX-induced conductance in a rapid and reversible manner; second, they competed with PX for a membrane binding site. In addition, Ca2+ (but not Mg2… CONTINUE READING
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