Modulation of platelet-activating-factor production by incorporation of naturally occurring 1-O-alkylglycerols in phospholipids of human leukemic monocyte-like THP-1 cells.

@article{Hichami1997ModulationOP,
  title={Modulation of platelet-activating-factor production by incorporation of naturally occurring 1-O-alkylglycerols in phospholipids of human leukemic monocyte-like THP-1 cells.},
  author={Aziz Hichami and V Duroudier and V{\'e}ronique Leblais and Laurent Vernhet and F le Goffic and Ewa Ninio and Agn{\`e}s Legrand},
  journal={European journal of biochemistry},
  year={1997},
  volume={250 2},
  pages={242-8}
}
1-O-Alkylglycerols (alkyl-Gro), naturally occurring compounds abundant in shark liver oil, protect patients from radiotherapy side-effects. However, the protection mechanism is not well understood. It might be mediated by alkyl-Gro incorporation into pools of platelet-activating factor (PAF) precursor and subsequent modification of PAF biosynthesis. Using a 3H-labelled or unlabelled natural alkyl-Gro mixture, in which prominent alkyl chains were C18:1(9) (54-65%), C16:1(7) (5-15.5%), and C16:0… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS