Modulation of photosensitization processes for an improved targeted photodynamic therapy.

@article{Verhille2010ModulationOP,
  title={Modulation of photosensitization processes for an improved targeted photodynamic therapy.},
  author={Marc Verhille and Pierre Couleaud and R{\'e}gis Vanderesse and Daniel Brault and Muriel Barberi-Heyob and C{\'e}line Frochot},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 32},
  pages={
          3925-43
        }
}
Photodynamic therapy (PDT) is a cancer treatment modality involving the combination of light, a photosensitizer (PS) and molecular oxygen, which results in the production of cytotoxic reactive oxygen species (ROS). Singlet oxygen ((1)O(2)) is one of the most important of these ROS. Because the lifetime and diffusion of (1)O(2) is very limited, a controllable singlet oxygen generation with high selectivity and localization would lead to more efficient and reliable PDT. The lack of selective… CONTINUE READING

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