Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity

@article{Lucas2001ModulationOP,
  title={Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity},
  author={Luisa Mar{\'i}a Lucas and Rub{\'e}n Hern{\'a}ndez-Alcoceba and Ver{\'o}nica Penalva and Juan Carlos Lacal},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={1110-1117}
}
Hexadecylphosphorylcholine (HePC, D-18506, INN: Mitelfosine) belongs to the family of alkylphosphocholines with anticancer activity. Previous reports have related its antitumoral activity to their ability to interfere with phospholipid metabolism. However a clear mechanism of action has not been established yet. We have investigated the effect of HePC on two enzymes recently reported to play a role in cell growth proliferation, phospholipase D (PLD) and choline kinase (ChoK). Our results… CONTINUE READING
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