Modulation of phenotypic and functional properties of normal human mononuclear phagocytes by granulocyte-macrophage colony-stimulating factor.

@article{Rivier1994ModulationOP,
  title={Modulation of phenotypic and functional properties of normal human mononuclear phagocytes by granulocyte-macrophage colony-stimulating factor.},
  author={A. Rivier and P. Chanez and J. P{\`e}ne and F. Michel and P. Godard and B. Dugas and J. Bousquet},
  journal={International archives of allergy and immunology},
  year={1994},
  volume={104 1},
  pages={
          27-32
        }
}
  • A. Rivier, P. Chanez, +4 authors J. Bousquet
  • Published 1994
  • Biology, Medicine
  • International archives of allergy and immunology
  • In asthma, alveolar macrophages (AMs) are hyperreactive releasing large amounts of mediators and expressing high levels of surface markers. Granulocyte-macrophage colony-stimulating factor (GM-CSF) upregulates monocytes and AMs, and may be involved in the hyperreactivity of AMs. The effects of GM-CSF were tested on monocytes and AMs from normal subjects by examining the expression of factors thought to be upregulated in asthma. After various incubation times of GM-CSF, the expression of CD23… CONTINUE READING
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