Modulation of phagolysosome biogenesis by the lipophosphoglycan of Leishmania.

  title={Modulation of phagolysosome biogenesis by the lipophosphoglycan of Leishmania.},
  author={Robert Lodge and Albert Descoteaux},
  journal={Clinical immunology},
  volume={114 3},
Promastigotes of the protozoan parasite Leishmania are inoculated into the mammalian host by an infected sandfly and are phagocytosed by macrophages. There, they differentiate into amastigotes, which replicate in phagolysosomes. A family of glycoconjugates, the phosphoglycans (PGs), plays an important role in the ability of promastigotes to survive the potentially microbicidal consequences of phagocytosis. Lipophosphoglycan (LPG), an abundant promastigote surface glycolipid, has received… CONTINUE READING


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