Modulation of phagocytosis by and lysosomal enzyme secretion from guinea-pig neutrophils: effect of nonsteroid anti-inflammatory agents and prostaglindins.

@article{Smith1977ModulationOP,
  title={Modulation of phagocytosis by and lysosomal enzyme secretion from guinea-pig neutrophils: effect of nonsteroid anti-inflammatory agents and prostaglindins.},
  author={Robert D. J. Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1977},
  volume={200 3},
  pages={647-57}
}
Guinea-pig neutrophils released lysosome granule-associated beta-glucuronidase, but not cytoplasmic lactate dehydrogenase during cell contact with and phagocytosis of serum-treated zymosan particles. Naproxen, chloroquine and indomethacin inhibited particle uptake by and lysosomal enzyme secretion from neutrophils incubated with zymosan in Krebs-Ringer phosphate medium, pH 7.4, at 37 degrees C. Acetylsalicyclic acid, fenoprofen and ibuprofen were inactive. Prostaglandins (PG) E1, E2, A1, A2, B1… CONTINUE READING
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