Modulation of peripheral μ-opioid analgesia by σ1 receptors.

  title={Modulation of peripheral μ-opioid analgesia by σ1 receptors.},
  author={Cristina S{\'a}nchez-Fern{\'a}ndez and {\'A}ngeles Montilla-Garc{\'i}a and Rafael Gonz{\'a}lez-Cano and Francisco R Nieto and Luc{\'i}a Romero and Antonia Artacho-Cord{\'o}n and Rosa Montes and Bego{\~n}a Fern{\'a}ndez-Pastor and Manuel Merlos and Jos{\'e} Manuel Baeyens and Jos{\'e} Manuel Entrena and Enrique Jos{\'e} Cobos},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={348 1},
We evaluated the effects of σ1-receptor inhibition on μ-opioid-induced mechanical antinociception and constipation. σ1-Knockout mice exhibited marked mechanical antinociception in response to several μ-opioid analgesics (fentanyl, oxycodone, morphine, buprenorphine, and tramadol) at systemic (subcutaneous) doses that were inactive in wild-type mice and even unmasked the antinociceptive effects of the peripheral μ-opioid agonist loperamide. Likewise, systemic (subcutaneous) or local… CONTINUE READING
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