Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein

@article{Colombo2003ModulationOP,
  title={Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein},
  author={Riccardo Colombo and Giulio F Draetta and Susanna Chiocca},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={2541-2547}
}
Gam1, an early adenoviral CELO protein, is required for viral replication. Consistent with its ability to inhibit histone deacetylation by HDAC1, Gam1 activates transcription. In this report, we identify the cellular transcription factor p120E4F as a Gam1 interaction partner. p120E4F is a low-abundance transcription factor that represses the adenovirus E4 promoter. Here we demonstrate that p120E4F interacts with HDAC1 in vivo and in vitro, and that E4F-mediated transcriptional repression is… CONTINUE READING