Modulation of oxidative stress and Ca2+ mobilization through TRPM2 channels in rat dorsal root ganglion neuron by Hypericum perforatum

@article{Nazrolu2014ModulationOO,
  title={Modulation of oxidative stress and Ca2+ mobilization through TRPM2 channels in rat dorsal root ganglion neuron by Hypericum perforatum},
  author={Mustafa Nazıroğlu and Bilal Çiğ and Cemil {\"O}zg{\"u}l},
  journal={Neuroscience},
  year={2014},
  volume={263},
  pages={27-35}
}
A main component of St. John's Wort (Hypericum perforatum, HP) is hyperforin which has antioxidant properties in dorsal root ganglion (DRG) neurons, due to its ability to modulate NADPH oxidase and protein kinase C. Recent reports indicate that oxidative stress through NADPH oxidase activates TRPM2 channels. HP may be a useful treatment for Ca(2+) entry and oxidative stress through modulation of TRPM2 channels in the DRG. We aimed to investigate the protective role of HP on Ca(2+) entry and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Anthranilic acid and heat inhibit TRPM8 channels of rat dorsal root ganglion neurons activated by noxious cold induced-allodynia and menthol

M Nazıroğlu, C Özgül
  • NeurochemRes
  • 2012
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Uğuz AC (2011a) Glutathione and 2-aminoethoxydiphenyl borate modulate Ca influx and oxidative stress through TRPM2 channel in rat dorsal root ganglion neurons

M Nazıroğlu, M Özgül, B Çiğ, S Doğan
  • J Membr Biol
  • 2011
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Role of TRPM2 in cell proliferation and susceptibility to oxidative stress.

  • American journal of physiology. Cell physiology
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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