Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells

Abstract

BACKGROUND Mucosal epithelia, including those of the oviduct, secrete antimicrobial innate immune molecules (AIIMS). These have bactericidal/bacteriostatic functions against a variety of pathogens. Among the AIIMs, sheep β-defensin-1 (SBD-1) is one of the most potent. Even though the SBD-1 is an important AIIM and it is regulated closely by estrogenic… (More)
DOI: 10.1186/1746-6148-8-143

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