Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses.

@article{Ralph2005ModulationOO,
  title={Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory joint disease involves adenosine A2A receptor-mediated responses.},
  author={Jennifer A. Ralph and Alice N. McEvoy and David Kane and Barry Bresnihan and Oliver FitzGerald and Evelyn Patricia Murphy},
  journal={Journal of immunology},
  year={2005},
  volume={175 1},
  pages={555-65}
}
Modulation by proinflammatory mediators indicate that NURR1 induction represents a point of convergence of distinct signaling pathways, suggesting an important common role for this transcription factor in mediating multiple inflammatory signals. The present study identifies NURR1 as a molecular target of methotrexate (MTX) action in human inflammatory joint disease and examines the mechanism through which MTX modulates NURR1 expression. MTX significantly suppresses expression of NURR1 in vivo… CONTINUE READING

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