Modulation of opioidergic system on mecamylamine-precipitated nicotine-withdrawal aversion in rats

@article{Ise2000ModulationOO,
  title={Modulation of opioidergic system on mecamylamine-precipitated nicotine-withdrawal aversion in rats},
  author={Yuya Ise and Minoru Narita and Hiroshi Nagase and Tsutomu Suzuki},
  journal={Psychopharmacology},
  year={2000},
  volume={151},
  pages={49-54}
}
Rationale: Several lines of evidence indicate that central opioid systems may be involved in the behavioral effects of nicotine. We previously reported that mecamylamine-precipitated nicotine-withdrawal aversion can be evaluated using the conditioned place preference paradigm. Objectives: In the present study, modulation of opioidergic systems in mecamylamine-precipitated nicotine-withdrawal aversion was investigated. Methods: Male Sprague-Dawley rats were chronically treated s.c. with 10 mg/kg… CONTINUE READING