Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions.

@article{Crain1998ModulationOO,
  title={Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions.},
  author={Stanley M. Crain and Ke Fei Shen},
  journal={Trends in pharmacological sciences},
  year={1998},
  volume={19 9},
  pages={358-65}
}
Studies of direct excitatory effects elicited by opioid agonists on various types of neurone have been confirmed and expanded in numerous laboratories following the initial findings reviewed previously by Stanley Crain and Ke-Fei Shen. However, the critical role of the endogenous glycolipid GM1 ganglioside in regulating Gs-coupled, excitatory opioid… CONTINUE READING