Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.

  title={Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.},
  author={Margaret R. Spitz and X ianchao Wu and Yiting Wang and Li E Wang and Sanjay Shete and Christopher I. Amos and Zhi-rong Guo and Lei Lei and Harvey W. Mohrenweiser and Qingyi Wei},
  journal={Cancer research},
  volume={61 4},
Sequence variations have been identified in a number of DNA repair genes, including XPD, but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We therefore examined XPD polymorphisms at Lys751Gln and Asp312Asn in 341 white lung cancer cases and 360 age-, sex-, ethnicity-, and smoking-matched controls accrued in a hospital-based molecular epidemiological study of susceptibility markers for lung cancer. As previously reported, DRC was statistically significantly lower… CONTINUE READING
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