Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core

@inproceedings{Fenley2018ModulationON,
  title={Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core},
  author={Andrew T. Fenley and Ramu Anandakrishnan and Yared H. Kidane and Alexey V Onufriev},
  booktitle={Epigenetics & Chromatin},
  year={2018}
}
BackgroundControlled modulation of nucleosomal DNA accessibility via post-translational modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs in the globular histone core—including acetylation, phosphorylation, crotonylation, propionylation, butyrylation, formylation, and citrullination—can alter the strong electrostatic interactions between the oppositely charged nucleosomal DNA and the histone proteins and thus modulate accessibility of the nucleosomal… CONTINUE READING
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