Modulation of nuclear pore topology by transport modifiers.

  title={Modulation of nuclear pore topology by transport modifiers.},
  author={Rainer D J{\"a}ggi and Alfredo Franco-Obreg{\'o}n and Petra M{\"u}hlh{\"a}usser and Franziska Thomas and Ulrike Kutay and Klaus Ensslin},
  journal={Biophysical journal},
  volume={84 1},
The nuclear pore complex (NPC) represents the only pathway for macromolecular communication between the nuclear and cytoplasmic compartments of the cell. Nucleocytoplasmic transport requires the interaction of transport receptors with phenylalanine-glycine (FG)-repeats that line the transport pathway through the NPC. Here we examine the effects of transport receptors and amphipathic alcohols on NPC topology using scanning force microscopy. We show that transport receptors that irreversibly bind… CONTINUE READING

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