Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus.

@article{Kalergis2009ModulationON,
  title={Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus.},
  author={Alexis M Kalergis and Mirentxu I. Iruretagoyena and Magaly J. Barrientos and Pablo A Gonz{\'a}lez and Andr{\'e}s Alonso Herrada and Eduardo D Leiva and M Angeles Guti{\'e}rrez and Claudia A Riedel and S. M. R. Bueno and Sergio H Jacobelli},
  journal={Immunology},
  year={2009},
  volume={128 1 Suppl},
  pages={e306-14}
}
Autoimmune diseases, such as systemic lupus erythematosus (SLE), result from deficiencies in self-antigen tolerance processes, which require regulated dendritic cell (DC) function. In this study we evaluated the phenotype of DCs during the onset of SLE in a mouse model, in which deletion of the inhibitory receptor FcgammaRIIb leads to the production of anti-nuclear antibodies and glomerulonephritis. Splenic DCs from FcgammaRIIb-deficient mice suffering from SLE showed increased expression of co… CONTINUE READING

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