Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction.

@article{Gillespie2012ModulationON,
  title={Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction.},
  author={James I. Gillespie and Stefano Palea and V{\'e}ronique Guilloteau and Marc Guerard and Philippe Lluel and Cees Korstanje},
  journal={BJU international},
  year={2012},
  volume={110 2 Pt 2},
  pages={E132-42}
}
UNLABELLED Experimental urethral obstruction in rats alters micturition patterns with non-voiding activity (NVA) during filling cystometry, showing similarity to that observed in human detrusor overactivity. Several drug classes with therapeutic potential in overactive bladder in humans have been tested in this model in rats, rabbits or guinea pigs, but no detailed analysis of drug effects on cystometric patterns has been published. The present study uses a rat model of overactivity with… CONTINUE READING
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Dose - ranging study of once - daily mirabegron ( YM - 178 ) a novel selective β 3 - adrenoceptor agonist in patients with overactive bladder ( OAB )

  • V Nitti, S Herschorn, S Auerbach
  • Eur Urol
  • 2010

Effects of the M 3 receptor selective muscarine antagonist darifenacin on bladder efferent activity of the rat pelvic nerve

  • K Iijima, S DeWachter, JJ Wyndaele
  • BJU Int
  • 2007

Suppression of phasic contractile activity of human detrusor strips by cyclic nucleotide Phosphodiesterase type 4 inhibition

  • C Chapple, JJ Wyndaele
  • Eur Urol
  • 2007

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