Modulation of nicotinic receptor function by opiate recognition sites highly selective for Met5-enkephalin[Arg6Phe7].

@article{Costa1983ModulationON,
  title={Modulation of nicotinic receptor function by opiate recognition sites highly selective for Met5-enkephalin[Arg6Phe7].},
  author={Erminio Costa and Alessandro Guidotti and Ingeborg Hanbauer and L Saiani},
  journal={Federation proceedings},
  year={1983},
  volume={42 12},
  pages={2946-52}
}
Adrenal medullary cells contain opiate recognition sites that cannot be classified with any of the accepted conventional criteria. In primary cultures of bovine adrenal chromaffin cells, stimulation of nicotinic receptors by acetylcholine causes an increase in the release of catecholamines. When the action of acetylcholine is studied in the presence of opiate receptor agonists, the acetylcholine secretory action is curtailed. The action of the opiates is stereoselective and is blocked by… CONTINUE READING