Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro

@article{Goggi2002ModulationON,
  title={Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro},
  author={Julian Luke Goggi and Ian A. Pullar and Stephen L. Carney and Henry F. Bradford},
  journal={Brain Research},
  year={2002},
  volume={941},
  pages={34-42}
}

• Julian Luke Goggi, Ian A. Pullar, +1 author Henry F. Bradford
• Published in Brain Research 2002
• DOI:10.1016/S0006-8993(02)02505-2

This study examined the influence of brain-derived neurotrophic factor (BDNF) on the basal and depolarisation-induced release of the neurotransmitters GABA, dopamine and serotonin from rat striatal brain slices in vitro. BDNF potentiated the potassium or veratrine-stimulated release of GABA, dopamine and serotonin. This potentiation was shown to be dependent on activation of the high-affinity tyrosine kinase-linked receptor TrkB, as K252a (a potent TrkB antagonist) largely prevented the effects… CONTINUE READING

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