Modulation of neurotransmitter action: control of the gamma-aminobutyric acid response through the benzodiazepine receptor.

  title={Modulation of neurotransmitter action: control of the gamma-aminobutyric acid response through the benzodiazepine receptor.},
  author={Cecilia K. Y. Chan and David H. Farb},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={5 9},
The ability of several homologous benzodiazepine and heterologous nonbenzodiazepine ligands to alter the conductance increase induced in spinal cord neurons by gamma-aminobutyric acid (GABA) was determined. Complete dose-response curves were carried out on individual neurons, reducing error introduced by cell-to-cell variability. The efficacies of modulation differ for "classical" benzodiazepines and novel nonbenzodiazepine drugs in a manner consistent with a model of control of GABA receptor… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 11 references

Benzodiazepine antagonist Ro 15-l 788: Neurological and behavrdral effects

E. P. Bonetti, L. Pieri, +3 authors R.K.E.R. Gamzu
cord. J. Neurochem • 1982
View 1 Excerpt

Benzodiazepines : Potentratron of a GABA inhibitory binding while sparing Pcarboline binding ( Hirsch , 1982 ; Mohler , 1982 ) . Thus , response in the dorsal raphe nucleus

J. D. Hirsch
Eur . J . Pharmacol . • 1978

Chlordiazepoxide thus , LY In condition 2 was Intermediate between conditions 1 and 3 . Values selectively augments GABA action in spinal cord cell cultures

D. H. Farb, G. D. Fischbach
Nature • 1977

A study of the action of picrotoxin

C. Braestrup, R. Schmiechen, G. Neff, M. Nielsen, N. Takeuchi
View 1 Excerpt

A modification of receptor theory

R. P. Stephenson
Br. J. Pharmacol • 1956
View 2 Excerpts

GABA reduces bindina of 3 Hmethvl& carboiine3carboxylate to brain benzodiazepine recept &

R. P. Stephenson
Nature 594 : Neuropharmacology • 1956
View 1 Excerpt

GABA - mediated + Ro 151788 40 + 44 + 19 3 synaptic potentials in chick spinal cord and sensory neurons

A. J. Clark
J . Neurophysiol .

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