Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice

@article{Eva2008ModulationON,
  title={Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice},
  author={C. Eva and P. Mele and D. Collura and A. Nai and M. G. Pisu and M. Serra and G. Biggio},
  journal={Journal of Neurochemistry},
  year={2008},
  volume={104}
}
  • C. Eva, P. Mele, +4 authors G. Biggio
  • Published 2008
  • Biology, Medicine
  • Journal of Neurochemistry
    • Previous studies have shown that GABAergic neuroactive steroids increase Y1 receptor (Y1R) gene expression in the amygdala of Y1R/LacZ transgenic mice, harbouring the murine Y1R gene promoter linked to a LacZ reporter gene. As ethanol is known to increase GABAergic neuroactive steroids, we investigated the relationship between fluctuations in the brain content of neuroactive steroids induced by chronic voluntary ethanol consumption or ethanol discontinuation and both the level of neuropeptide Y… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    14 Citations
    Background Citations
    6
    Methods Citations
    1
    14 Citations
    Citation Type

    Citation Type

    Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity.
    • 4
    NPY‐Y1 coexpressed with NPY‐Y5 receptors modulate anxiety but not mild social stress response in mice
    • 18
    • PDF
    Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype
    • 22
    Sex Differences in Ethanol’s Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene
    • 17
    Effects of different ethanol-administration regimes on mRNA and protein levels of steroid 5α-reductase isozymes in prefrontal cortex of adolescent male rats
    • 8
    Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain
    • 1
    • PDF
    Adult exposure to tributyltin affects hypothalamic neuropeptide Y, Y1 receptor distribution, and circulating leptin in mice
    • 21
    • PDF
    Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner
    • 9
    Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors
    • 57
    The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders
    • 187
    • PDF

    References

    SHOWING 1-10 OF 86 REFERENCES
    Increased expression of the neuropeptide Y receptor Y1 gene in the medial amygdala of transgenic mice induced by long‐term treatment with progesterone or allopregnanolone
    • 33
    Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery
    • 14
    Role of brain neuroactive steroids in the functional interplay between the GABAA and the NPY-Y1 receptor mediated signals in the amygdala
    • 16
    Chronic modulation of the GABAA receptor complex regulates Y1 receptor gene expression in the medial amygdala of transgenic mice
    • 33
    The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure.
    • A. Roy, S. Pandey
    • Chemistry, Medicine
    • Alcoholism, clinical and experimental research
    • 2002
    • 132
    Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure.
    • 167
    Chronic Intermittent Ethanol Treatment in Rats Increases GABAA Receptor α4‐Subunit Expression: Possible Relevance to Alcohol Dependence
    • 154
    Social isolation‐induced increase in α4 and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAA receptor function
    • 49
    Intra-amygdala infusion of the NPY Y1 receptor antagonist BIBP 3226 attenuates operant ethanol self-administration.
    • 59
    Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawal
    • 60