Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice

@article{Eva2008ModulationON,
  title={Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice},
  author={C. Eva and P. Mele and D. Collura and A. Nai and M. G. Pisu and M. Serra and G. Biggio},
  journal={Journal of Neurochemistry},
  year={2008},
  volume={104}
}
  • C. Eva, P. Mele, +4 authors G. Biggio
  • Published 2008
  • Biology, Medicine
  • Journal of Neurochemistry
  • Previous studies have shown that GABAergic neuroactive steroids increase Y1 receptor (Y1R) gene expression in the amygdala of Y1R/LacZ transgenic mice, harbouring the murine Y1R gene promoter linked to a LacZ reporter gene. As ethanol is known to increase GABAergic neuroactive steroids, we investigated the relationship between fluctuations in the brain content of neuroactive steroids induced by chronic voluntary ethanol consumption or ethanol discontinuation and both the level of neuropeptide Y… CONTINUE READING
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