Modulation of natural killer cell activity by restraint stress during an influenza A/PR8 infection in mice

@article{Hunzeker2004ModulationON,
  title={Modulation of natural killer cell activity by restraint stress during an influenza A/PR8 infection in mice},
  author={John Hunzeker and David A. Padgett and Patricia A. Sheridan and Firdaus S. Dhabhar and John F Sheridan},
  journal={Brain, Behavior, and Immunity},
  year={2004},
  volume={18},
  pages={526-535}
}
These experiments were designed to examine the influences of restraint stress (RST) on natural killer (NK) activity and to determine its consequences on influenza A/PR8 (A/PR8) viral replication in mice. The data showed that RST delayed the recruitment of NK1.1+ cells into the lung parenchyma during infection. Quantification of MIP-1alpha and MCP-1 gene expression by real-time PCR revealed that RST suppressed the chemokines responsible for NK cell recruitment into the infected tissue… CONTINUE READING

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