Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: insight into ischemia-induced reduction in endothelium-dependent vasodilatation.

@article{Laham1998ModulationOM,
  title={Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: insight into ischemia-induced reduction in endothelium-dependent vasodilatation.},
  author={Roger J. Laham and Michael Simons and Motohisa Tofukuji and D S Hung and Frank W Sellke},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1998},
  volume={116 6},
  pages={1022-8}
}
OBJECTIVES The present study was designed to study the effects of a single intrapericardial injection of basic fibroblast growth factor on myocardial vascular resistance and endothelium-dependent microvascular dilatation in a porcine model of chronic myocardial ischemia and to investigate the mechanism of ischemia-induced impairment of endothelium-dependent vasodilatation. METHODS Yorkshire pigs underwent ameroid constrictor placement on the left circumflex coronary artery. At 3 weeks… CONTINUE READING

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