Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity.

  title={Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity.},
  author={Alejandro Peralta Soler and G Gilliard and Louis C Megosh and Thomas G. O'Brien},
  journal={The Journal of investigative dermatology},
  volume={106 5},
Mice that overexpress a mutated ornithine decarboxylase (ODC) transgene in outer root sheath keratinocytes of the hair follicle were used to study the role of this enzyme in regulating hair follicle structure and function. These transgenic mice have a normal first hair cycle, but lose their hair completely beginning 2-3 wk after birth. Transgene overexpression in follicular keratinocytes is first detected at day 12 after birth, coincident with the development of follicular cysts in the upper… CONTINUE READING
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ill cutancous papillom:ts in SEN C AR mice is associa ted with ahercd exprcssion of kera tins I alld 10. Cnllce/' n cs

  • AK TakigaaM.Verma
  • 1994

Randomized - phase I chemoprcvcntion dose - seeking study of a - d i - flu oromcthylontithinc

  • PP LoveR..R.Carbonc, AK Venun, D Gilrnore
  • 1993

Cyclic hair - loss ; md regrowth ill transgenic mice o \ lcrcxpress - iug : 11 l intennediarc filam enl gene

  • GE PowellDC.H..ogers
  • Ekl BO J
  • 1990

Til e Diolog } ' t ! f H cmi IJ . . . C tlml D cafiu ' . ' iS . C harles C . T homas . Springfie ld . IL .

  • RU Harrison
  • 1988

: Induction of the polyamine biosynthctic enzymcs in mouse epide rmis and their specifi city fo r [ lImor promotion

  • Sun T-T, G O'DricllT, K SimsimanRC.BoutwcllR.

Abnormal o rnithine carbamoylrran sfera se in mi ce having the sparse - fur mutation

  • R DeMars, BL Trend, LD Russell
  • Pror Na t ! Acad Sri USA

Boone CW o C hro " ic tOxicit ) , studies of the po tential Cancer prevcnrivc 2 - ( difluoro 111 crhyl ) - dl - ornirhine

  • Golde, GJ Kellofr
  • FlI / lllmll Jlpl ' l T oxicol

Constitutivel y elevated levels of a nli thillc ; ' lild polyamincs in mouse epidermal papillom as

  • RA Koza, TG PalmieriM.O'Brien
  • Cart ; ' lo . ~ t · IICS ; S ( Loud )

Hair loss and cyst fo rmation in hairless : U 1 d rh in o Illutant mice

  • Mann Sj

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