Modulation of multidrug resistance by verapamil or mdr1 anti-sense oligodeoxynucleotide does not change the high susceptibility to lymphokine-activated killers in mdr-resistant human carcinoma (LoVo) line.

@article{Rivoltini1990ModulationOM,
  title={Modulation of multidrug resistance by verapamil or mdr1 anti-sense oligodeoxynucleotide does not change the high susceptibility to lymphokine-activated killers in mdr-resistant human carcinoma (LoVo) line.},
  author={Licia Rivoltini and Mario P Colombo and Rosanna Supino and Dario Ballinari and Takashi Tsuruo and Giorgio Parmiani},
  journal={International journal of cancer},
  year={1990},
  volume={46 4},
  pages={
          727-32
        }
}
Two sublines were derived from the colon adenocarcinoma line LoVo, the first one was sensitive (LoVo/H) and the second one was made resistant to doxorubicin (LoVo/Dx). When tested for susceptibility to lysis by different types of immune effectors, LoVo/Dx appeared more sensitive than LoVo/H to the killing of CD3+CD5+CD16-, CD3- CD16+)-enriched lymphokine activated killers (LAK) or activated macrophages. In order to check whether this effect was due to different expression of glycoprotein P170… CONTINUE READING

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Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance.

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