Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.

@article{Kobayashi1998ModulationOM,
  title={Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.},
  author={Jun’ichi Kobayashi and Hirokazu Hosoyama and Xiao Xiong Wang and Hideyuki Shigemori and Yoshihisa Sudo and Takashi Tsuruo},
  journal={Bioorganic & medicinal chemistry letters},
  year={1998},
  volume={8 12},
  pages={
          1555-8
        }
}
Taxuspine C (1), a new taxoid from the Japanese yew Taxus cuspidata, increasing the cellular accumulation of vincristine (VCR) in multidrug-resistant tumor cells as potent as verapamil enhanced the chemotherapeutic effect of VCR in P388/VCR-bearing mice. When taxuspine C (1) was given i.p. daily at 200 mg/kg with 0.2 mg/kg VCR for 5 days, a treated/control (T/C) value of 138% was obtained. The other new taxoids, taxezopidines G (8) and H (9), from the yew also increased the VCR accumulation as… CONTINUE READING
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