Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes.

@article{Tian2004ModulationOM,
  title={Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes.},
  author={Xianbin Tian and Maciej J. Zamek-Gliszczynski and Peijin Zhang and Kim L R Brouwer},
  journal={Molecular pharmacology},
  year={2004},
  volume={66 4},
  pages={1004-10}
}
Canalicular multidrug resistance-associated protein 2 (Mrp2) and basolateral Mrp3 mediate the excretion of organic anions, including conjugated and unconjugated xenobiotics and bile acids, from the liver. The utility of RNA interference to specifically knock down the expression and function of transport proteins was demonstrated in sandwich-cultured rat hepatocytes, which exhibit functional and properly localized Mrp2 and Mrp3 over time in culture. Specific knockdown of Mrp2 (approximately 50… CONTINUE READING
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