Modulation of mu-mediated antitussive activity in rats by a delta agonist.

@article{Kamei1991ModulationOM,
  title={Modulation of mu-mediated antitussive activity in rats by a delta agonist.},
  author={Junzo Kamei and Hidenobu Tanihara and Yutaka Kasuya},
  journal={European journal of pharmacology},
  year={1991},
  volume={203 1},
  pages={153-6}
}
Effects of selective mu and delta receptor agonists on capsaicin-induced cough reflex in rats were studied. Intracisternal injection (i.cist.) of a selective mu receptor agonist [D-Ala2,Mephe4,Gly-ol5]enkephalin (DAMGO) produced dose-related depression of coughs over the 0.003-0.03 nmol dose range. The antitussive potency of DAMGO was 100-fold more potent than morphine. The antitussive effects of DAMGO and morphine were significantly reduced by naloxone (1 nmol i.cist.). The selective delta… CONTINUE READING
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