Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.

  title={Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.},
  author={Kiyoshi Mori and Riko Kitazawa and Takeshi Kondo and Sakan Maeda and Akira Yamaguchi and Sohei Kitazawa},
  journal={Journal of cellular biochemistry},
  volume={98 6},
Runx2 regulates the target genes characteristic of osteoblastic phenotypes, while exerting diverse and sometimes controversial effects on osteoblastic cells depending on their differentiation stage. Receptor activator of nuclear factor-kappaB (RANK) ligand (RANKL) is a membrane bound cytokine essential for osteo(chondro)clastogenesis. During endochondral ossification, while Runx2-positive hypertrophic chondrocytes express RANKL, the steady-state expression of the RANKL gene in osteoblastic… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…