Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.

@article{Mori2006ModulationOM,
  title={Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.},
  author={Kiyoshi Mori and Riko Kitazawa and Takeshi Kondo and Sakan Maeda and Akira Yamaguchi and Sohei Kitazawa},
  journal={Journal of cellular biochemistry},
  year={2006},
  volume={98 6},
  pages={1629-44}
}
Runx2 regulates the target genes characteristic of osteoblastic phenotypes, while exerting diverse and sometimes controversial effects on osteoblastic cells depending on their differentiation stage. Receptor activator of nuclear factor-kappaB (RANK) ligand (RANKL) is a membrane bound cytokine essential for osteo(chondro)clastogenesis. During endochondral ossification, while Runx2-positive hypertrophic chondrocytes express RANKL, the steady-state expression of the RANKL gene in osteoblastic… CONTINUE READING

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