Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome.

@article{Mantovani2013ModulationOM,
  title={Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome.},
  author={Antonio Mantovani and Simone Rossi and Bruce D Bassi and H. Blair Simpson and Brian A. Fallon and Sarah H. Lisanby},
  journal={Psychiatry research},
  year={2013},
  volume={210 3},
  pages={1026-32}
}
Low-frequency repetitive transcranial magnetic stimulation (rTMS) to supplementary motor area (SMA) showed clinical benefit in obsessive-compulsive disorder (OCD). Here we tested whether clinical improvement was associated with enhanced cortical inhibition as measured by single and paired-pulse TMS variables. In 18 OCD patients receiving 4 weeks of either active or sham rTMS in a double-blind randomized trial, we assessed bilateral resting and active motor thresholds (RMT and AMT), cortical… CONTINUE READING
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