Modulation of morphine-induced antinociception in mice by histamine H3-receptor ligands


The effects of compounds active at histamine H3-receptors on morphine-induced antinociception have been investigated in thermal and chemical tests in mice; tail-immersion (50°C) and hot-plate (49° and 55°C) tests and acetic acid-induced writhing. Neither (R)α-methylhistamine, a specific agonist, (S)α-methylhistamine, a chemical control, nor thioperamide, an antagonist, had any antinociceptive action alone but thioperamide (3 mg kg−1) attenuated the effects of morphine in the tailimmersion test wile (R)α-methylhistamine (1 mg kg−1), but not the (S) isomer, potentiated its effects in the hot-plate test at 55°C. These results are consistent with the morphine potentiation seen with H1-antagonists and suggest that central histaminergic mechanisms can modulate opioid actions.

DOI: 10.1007/BF02007768

1 Figure or Table

Citations per Year

623 Citations

Semantic Scholar estimates that this publication has 623 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Owen1994ModulationOM, title={Modulation of morphine-induced antinociception in mice by histamine H3-receptor ligands}, author={Sue M Owen and Gillian Sturman and Pierre Freeman}, journal={Agents and Actions}, year={1994}, volume={41}, pages={C62-C63} }