Modulation of morphine-induced antinociception in mice by histamine H3-receptor ligands

Abstract

The effects of compounds active at histamine H3-receptors on morphine-induced antinociception have been investigated in thermal and chemical tests in mice; tail-immersion (50°C) and hot-plate (49° and 55°C) tests and acetic acid-induced writhing. Neither (R)α-methylhistamine, a specific agonist, (S)α-methylhistamine, a chemical control, nor thioperamide, an antagonist, had any antinociceptive action alone but thioperamide (3 mg kg−1) attenuated the effects of morphine in the tailimmersion test wile (R)α-methylhistamine (1 mg kg−1), but not the (S) isomer, potentiated its effects in the hot-plate test at 55°C. These results are consistent with the morphine potentiation seen with H1-antagonists and suggest that central histaminergic mechanisms can modulate opioid actions.

DOI: 10.1007/BF02007768

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@article{Owen1994ModulationOM, title={Modulation of morphine-induced antinociception in mice by histamine H3-receptor ligands}, author={Sue M Owen and Gillian Sturman and Pierre Freeman}, journal={Agents and Actions}, year={1994}, volume={41}, pages={C62-C63} }