Modulation of morphine and alcohol motor stimulant effects by cannabinoid receptors ligands.

@article{Hagues2007ModulationOM,
  title={Modulation of morphine and alcohol motor stimulant effects by cannabinoid receptors ligands.},
  author={Guillaume Hagues and Jean Costentin and Dominique Duterte-Boucher},
  journal={Behavioural brain research},
  year={2007},
  volume={178 2},
  pages={274-82}
}
Previous studies evidenced in rats the suppression by cannabinoids of motor stimulant effects of various drugs of abuse. Here we investigated, in mice, the effects of an acute or a chronic administration with the cannabinoid agonist HU 210 on the motor stimulant effects of either morphine or alcohol. HU 210 (12.5-200 microg/kg), when acutely administered, antagonized the stimulant effects of morphine (7.5 mg/kg) or alcohol (1 or 1.5 g/kg). A tolerance to this antagonistic interaction with… CONTINUE READING