Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm)

@article{Kennedy2002ModulationOM,
  title={Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm)},
  author={David O. Kennedy and Andrew Scholey and Nicola T. J. Tildesley and Elaine K. Perry and Keith A Wesnes},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={72},
  pages={953-964}
}

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References

SHOWING 1-10 OF 42 REFERENCES
The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers
TLDR
The Ginkgo/ginseng combination was found significantly to improve an Index of Memory Quality, supporting a previous finding with the compound and represents the first substantial demonstration of improvements to the memory of healthy middle-aged volunteers produced by a phytopharmaceutical.
Dose Dependent Changes in Cognitive Performance and Mood following Acute Administration of Ginseng to Healthy Young Volunteers
TLDR
There was a significant improvement in “Quality of Memory” and the associated “Secondary memory” factor at all time points following 400 mg of Ginseng, and this represents the first demonstration of a modulation of mood and cognitive performance by acute administration of Ginsang.
The cognitive, subjective, and physical effects of a ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints.
TLDR
On Day 90 at 1 hour post morning dosing, dose-related improvements were seen on the CDR tests, and there were also several supporting changes from other assessments, including an advantage of 320 mg over placebo on the global score from the Symptom Checklist-90-revised (SCL- 90-R) at Day 90.
Acute, dose‐dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand
TLDR
Three studies examining the acute effects of single doses of Ginkgo biloba, Ginseng and their combination on the performance of healthy young adults during serial arithmetic tasks with differing cognitive load during Serial Threes and Serial Sevens are described.
The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers
TLDR
It is concluded that acute administration of Ginkgo biloba is capable of producing a sustained improvement in attention in healthy young volunteers and can be useful to describe cognitive function changes.
EUROPEAN HERBS WITH CHOLINERGIC ACTIVITIES: POTENTIAL IN DEMENTIA THERAPY
TLDR
Of three plants with reputed memory enhancing properties, extracts of sage (Salvia officinalis) inhibited the brain enzyme in a concentration dependant manner, indicating that the active plant constituent(s) may be an as yet unidentified compound(s).
Differential, Dose Dependent Changes in Cognitive Performance Following Acute Administration of a Ginkgo biloba/Panax ginseng Combination to Healthy Young Volunteers
TLDR
The most striking result was a dose-dependent improvement in performance on the “quality of memory” factor for the highest dose, and further analysis revealed that this effect was differentially targeted at the secondary memory rather than the working memory component.
Medicinal Plant Extracts for the Treatment of Dementia
TLDR
Current available data indicate galantamine to be well tolerated in the long term, with a relative lack of toxicity at clinically effective dosages, and future development of effective novel therapeutic strategies for dementia may benefit from the combination of conventional Western medical science and traditional Oriental medical practices.
Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.
TLDR
The finding that aromatherapy with essential balm oil is a safe and effective treatment for clinically significant agitation in people with severe dementia, with additional benefits for key quality of life parameters, indicates the need for further controlled trials.
...
...