Modulation of monocyte type I transforming growth factor-beta receptors by inflammatory stimuli.

@article{Brandes1991ModulationOM,
  title={Modulation of monocyte type I transforming growth factor-beta receptors by inflammatory stimuli.},
  author={M E Brandes and Lalage M. Wakefield and Sharon M. Wahl},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 29},
  pages={19697-703}
}
The regulatory mechanisms which control the wide array of cellular responses to transforming growth factor beta (TGF beta) are not understood. This report presents evidence that down-regulation of TGF beta receptors on human monocytes may be one mechanism by which the effects of TGF beta are regulated. Treatment of monocytes with interferon gamma (IFN gamma) and lipopolysaccharide for 18 h reduced monocyte receptor number (approximately 400/cell) in a dose-dependent fashion by 89 and 78… CONTINUE READING

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