Modulation of monocyte adherence to endothelial cells by endothelin-1 involvement of Src (p60src) and JAK1-like kinases.

@article{Chisholm1996ModulationOM,
  title={Modulation of monocyte adherence to endothelial cells by endothelin-1 involvement of Src (p60src) and JAK1-like kinases.},
  author={Lindsey J. Chisholm and Peter S. Dovgan and Devendra K. Agrawal and Peter McGregor and John D. Edwards},
  journal={Journal of vascular surgery},
  year={1996},
  volume={23 2},
  pages={
          288-300
        }
}
PURPOSE The purpose of this study was to determine the transmembrane signaling pathway by which endothelin-1 (ET-1) enhances monocyte adherence to human umbilical vein endothelial cells (HUVECs) and to investigate the role of tyrosine kinases in this mechanism. METHODS Adherence of purified human blood monocytes to HUVEC monolayers was assessed with radiolabeled monocytes. Tyrosine kinase activation was examined by immunoprecipitation and Western blotting. RESULTS ET-1 potentiated monocyte… CONTINUE READING