Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation.

@article{Caraglia2000ModulationOM,
  title={Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation.},
  author={Michele Caraglia and Alfredo Budillon and Giovanni Vitale and Giovanni Lupoli and Pierosandro Tagliaferri and Alberto Abbruzzese},
  journal={European journal of biochemistry},
  year={2000},
  volume={267 13},
  pages={
          3919-36
        }
}
In the past years, the attention of scientists has focused mainly on the study of the genetic information and alterations that regulate eukaryotic cell proliferation and that lead to neoplastic transformation. All therapeutic strategies against cancer are, to date, directed at DNA either with cytotoxic drugs or gene therapy. Little or no interest has been aroused by protein synthesis mechanisms. However, an increasing body of data is emerging about the involvement of translational processes and… Expand
Proapoptotic role of novel gene-expression factors
The mechanisms that control cellular proliferation, as well as those related with programmed cell death or apoptosis, require precise regulation systems to prevent diseases such as cancer. EventsExpand
Proapoptotic role of novel gene-expression factors
TLDR
This review focuses on the interactions established between different families of transcription, elongation, translation and splicing factors associated to the progression of apoptosis. Expand
Translational and post-translational modifications of proteins as a new mechanism of action of Alpha-Interferon: Review article
TLDR
Data obtained strongly suggest that the antitumour activity of IFNα against human tumours could involve still unexplored mechanisms based on post-translational and translational control of the expression of proteins that regulate cell proliferation and apoptosis. Expand
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines.
TLDR
Screening of a series of imidazolium histidine kinase inhibitors and the identification of an active lead compound, NH125, suggest that identification of potent inhibitors of eEF-2 kinase may lead to the development of new types of anticancer drugs. Expand
Identification and Characterization of an Inhibitor of Eukaryotic Elongation Factor 2 Kinase against Human Cancer Cell Lines 1
Recent evidence suggests that the machinery of protein synthesis may provide novel targets for anticancer drugs. For example, aberrations in protein synthesis are commonly encountered in establishedExpand
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: Review article
TLDR
This article summarizes the present knowledges on the several extra-translational roles of eEF1A also in order to understand as the protein synthesis regulatory mechanisms could offer tools for cancer intervention. Expand
HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation
TLDR
Evidence shows that cAMP governs HOPS export in hepatocytes of normal and regenerating liver and is mediated via CRM-1, and it is demonstrated that HOPS binds to elongation factor eEF-1A and interferes in protein synthesis. Expand
The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
TLDR
It is indicated that eEF1A proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis. Expand
eIF5A isoforms and cancer: two brothers for two functions?
TLDR
The involvement of eIF5A-1 in the triggering of an apoptotic program and in the regulation of cell proliferation are focused on. Expand
The emerging roles of translation factor eIF4E in the nucleus.
TLDR
This review will focus on the novel, nuclear functions of eif4E and how they contribute to eIF4E's growth-activating and oncogenic properties. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 254 REFERENCES
The protein kinase ABC's of signal transduction as targets for drug development.
  • R. Glazer
  • Chemistry, Medicine
  • Current pharmaceutical design
  • 1998
TLDR
These protein kinases are potentially important targets for antisense oligonucleotide therapy, and therefore may provide a means of selectively inhibiting tumor proliferation and inducing apoptosis with minimal nonspecific cytotoxicity. Expand
eIF4E expression in tumors: its possible role in progression of malignancies.
TLDR
Analysis of cells transformed by eIF4E revealed that the synthesis of only a few proteins was greatly enhanced, while synthesis of most was minimally increased, suggesting that establishing a greater protein synthesis output may be a necessary step for cancer cells in order to sustain their rapid proliferation. Expand
Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis
TLDR
It is found that eIF-4E is increased in colon adenomas and carcinomas, and this increase is accompanied in most but not all cases by elevation of cyclin D1 levels, consistent with the view that eif-4e plays a role in carcinogenesis by increasing general protein synthesis and by preferentially upregulating a subset of putative growth promoting proteins. Expand
Translational infidelity and human cancer: role of the PTI-1 oncogene.
TLDR
It is proposed that PTI-1 represents a new class of oncogene whose transforming capacity probably arises through mechanisms including: (i) protein translational infidelity, resulting in the synthesis of mutant polypeptides due to loss of proofreading function during peptide chain elongation, and (ii) by its association with and alteration of the cytoskeleton, by impinging on one particular or several different signal transduction pathways through its properties as a G-protein. Expand
Initiation of protein synthesis in eukaryotic cells.
  • V. M. Pain
  • Biology, Medicine
  • European journal of biochemistry
  • 1996
TLDR
This review aims to assess recent progress in structure and function of initiation factors, physiological regulation of initiation factor activities and identification of features in the 5' and 3' untranslated regions of messenger RNA molecules that regulate the selection of these mRNAs for translation. Expand
Mechanism and regulation of eukaryotic protein synthesis.
  • W. Merrick
  • Biology, Medicine
  • Microbiological reviews
  • 1992
This review presents a description of the numerous eukaryotic protein synthesis factors and their apparent sequential utilization in the processes of initiation, elongation, and termination.Expand
Pharmacological modulation of peptide growth factor receptor expression on tumor cells as a basis for cancer therapy.
TLDR
Therapeutic opportunities related to the pharmacologic modulation of PGF-R expression are reviewed and a mechanistic hypothesis regarding P GF-R upregulation induced by cytostatic drugs and cytokines is proposed. Expand
Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis*
  • R. Rhoads
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 1999
TLDR
This article summarizes recent advances in the understanding of how a single mitogenic stimulus can simultaneously lead to an increase in both global and growth-regulated protein synthesis. Expand
Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates.
: Elongation factor 2 (eEF-2) is a 100-kD protein that catalyzes the ribosomal translocation reaction, resulting in the movement of ribosomes along mRNA. eEF-2 is the target for a very specificExpand
PKR, apoptosis and cancer.
TLDR
Although PKR plays an important role in mediating the antiviral effects of interferons, PKR is also implicated in regulating cell proliferation in uninfected cells and may have a tumor suppressor function under normal conditions. Expand
...
1
2
3
4
5
...