Modulation of mitochondrial Ca(2+) homeostasis by Bcl-2.

  title={Modulation of mitochondrial Ca(2+) homeostasis by Bcl-2.},
  author={Ling Ping Zhu and Shizhang Ling and Xiao Dong Yu and L. K. Venkatesh and Thangaiah Subramanian and G. Chinnadurai and Tuan H. Kuo},
  journal={The Journal of biological chemistry},
  volume={274 47},
We have investigated the role of mitochondrial Ca(2+) (Ca(m)) homeostasis in cell survival. Disruption of Ca(m) homeostasis via depletion of the mitochondrial Ca(2+) store was the earliest event that occurred during staurosporine-induced apoptosis in neuroblastoma cells (SH-SY5Y). The decrease of Ca(m) preceded activation of the caspase cascade and DNA… CONTINUE READING