Modulation of migration and Ca2+ signaling in retinal pigment epithelium cells by recombinant human CTGF.

@article{Guo2009ModulationOM,
  title={Modulation of migration and Ca2+ signaling in retinal pigment epithelium cells by recombinant human CTGF.},
  author={Chang-mei Guo and Yu-sheng Wang and Dan Hu and Quan-hong Han and Jing-bo Wang and Xu Wei Hou and Yan-nian Hui},
  journal={Current eye research},
  year={2009},
  volume={34 10},
  pages={852-62}
}
PURPOSE The migration of retinal pigment epithelium (RPE) cells is an initial step in the development of proliferative vitreoretinopathy (PVR). We investigated the expression of connective tissue growth factor (CTGF) in an in vitro model of wound healing and effects of recombinant human CTGF (rhCTGF) on modulating migration and Ca(2+) signaling in RPE cells. METHODS Cultured human RPE monolayers were used to establish a wound-healing model. Western blot and in situ hybridization were used to… CONTINUE READING
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